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    Dr. Sara George Muthoot receiving the Lifetime Achievement Award from Ambassador Deepak Vohra, Former Indian Diplomat and Special Advisor, at a ceremony held in New Delhi

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    10 Transformative Innovations for Climate Action and Planetary Health

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    Supercomputing India 2025 Sets the Stage for HPC, AI, and Quantum Innovation

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    “It’s our way of adding an extra spark to the festive season, making it more joyful and memorable for everyone.”-Ms. Kamakshi Mantri- CSO, Mantri Square Mall

    TTD Approves New Tirupati Temple in Mangaluru: TTD Member S Naresh Kumar

    Malabar Gold & Diamonds Opens its Showroom at Vaishali Enclave, Pitampura, Inaugurated By Bollywood Star Anil Kapoor

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Merck Announces Out-Licensing Agreement for Investigational Atacicept with Vera Therapeutics

by FWM
November 9, 2020
in World
0

Merck campus from bird's eye perspective in Darmstadt, Germany. View over Emanuel-Merck-Platz (square) to the Innovation Center in Darmstadt, Germany

Merck today announced that it has entered into an out-licensing agreement with biotechnology company Vera Therapeutics, South San Francisco, for the further development of investigational therapy atacicept.

09 Nov 2020 | Darmstadt, Germany
  • Merck out-licenses Phase IIb-ready atacicept to Vera Therapeutics
  • Phase IIa trial conducted by Merck shows promising results in IgA nephropathy (IgAN), also known as “Berger’s disease”
  • Out-licencing deal includes 10% equity in Vera Therapeutics and up to € 605 million in development and commercial milestones, plus royalties on any future net sales

Merck, a leading science and technology company, today announced that it, through its subsidiary Ares Trading S.A., has entered into an out-licensing agreement with biotechnology company Vera Therapeutics, South San Francisco, USA, for the further development of investigational therapy atacicept. Vera Therapeutics will first prioritize to take atacicept into a Phase IIb study in IgA nephropathy (IgAN), an autoimmune kidney disease also known as “Berger’s disease”.

“The positive results from our Phase IIa study in IgA nephropathy reinforce the potential of this compound, and we are pleased to see Vera Therapeutics take it into the next phase of development,” says Andreas Stickler, Chief Financial Officer and Head of Strategy, Business Development and Portfolio Management of the healthcare business sector of Merck. “This agreement shows how we are executing on our strategy to focus on our priority assets and areas of expertise, while underscoring our commitment to ensure promising molecules from our immunology pipeline have the opportunity to make it to patients as quickly as possible.”

Atacicept is a recombinant fusion protein that contains the soluble TACI receptor that binds to the cytokines BLyS and APRIL. These cytokines are members of the tumor necrosis factor family that promote B-cell survival and autoantibody production associated with certain autoimmune diseases such as IgAN. IgAN is one of the most common kidney diseases worldwide, with a remaining high unmet medical need for efficacious new medications to treat the disease.

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As part of the agreement, Merck will receive 10% equity in Vera Therapeutics, up to a total of € 605 million related to delivering on certain development and commercial milestones, plus royalties on any future net sales. Vera Therapeutics will assume full responsibility for the development and commercialization of the atacicept program in all indications. A Phase IIb study in IgAN is planned to start in the second quarter of 2021.

JANUS, a Phase IIa, randomized, double-blind, placebo-controlled study evaluating the efficacy and safety of atacicept in IgA nephropathy showed a dose dependent effect of atacicept on key biomarkers, i.e. serum immunoglobulin levels and proteinuria, and at the same time a favourable safety profile. These data were awarded to be among the “Absolute Best Abstracts” at the annual meeting of the European Renal Association (ERA-EDTA) in June and were recently presented by Dr. Jonathan Barratt, University of Leicester, UK, in an encore virtual talk during the American Society of Nephrology (ASN) Kidney week, October 20-25, 2020.

Merck acquired exclusive worldwide development and commercialization rights for atacicept from Zymogenetics in 2008 (Zymogenetics was acquired by Bristol-Myers Squibb in 2010). The asset has since then been solely developed by Merck.

Tags: Merck

FWM

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