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  • Home
  • World

    Export Surge: India Steps Up on Global Stage

    Omkar, Grade 10 student at Canadian International School (CIS), Bangalore.

    CIS Student Omkar Earns Global Recognition with Distinctions in Music and International Violin Performance

    Passenger Demand Grows 4.6% in August

    UPDATE ON ING’S EXIT FROM THE RUSSIAN MARKET

    World leaders show strong support for political declaration on noncommunicable diseases and mental health

    150 students complete Sona Group’s Xccelerator 2.0 Programme powered by Unreal Engine, Dassault

  • National
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    PM to visit Maharashtra on 8-9th October

    Celebrating fashion, creativity, and craftsmanship on the red carpet at Timex IBFW Showcase

    Timex India Set to Elevate Fashion Trends as Title Sponsor of 11th Edition of India Beach Fashion Week

    Herbalife India Launches Liftoff® – A Zero Added Sugar Effervescent Drink

    Herbalife India Launches Liftoff® – A Zero Added Sugar Effervescent Drink

    The (NALSA), in collaboration with the (MCPC) of the Supreme Court of India, 90-day “Mediation for the Nation” campaign concludes.

    Omkar, Grade 10 student at Canadian International School (CIS), Bangalore.

    CIS Student Omkar Earns Global Recognition with Distinctions in Music and International Violin Performance

    Phoenix Mall of Asia, Bengaluru Hosts Spectacular Grand Finale of Phoenix Mega Model Hunt 2025

  • Business

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    Herbalife India Launches Liftoff® – A Zero Added Sugar Effervescent Drink

    Herbalife India Launches Liftoff® – A Zero Added Sugar Effervescent Drink

    Chief Minister Siddaramaiah inaugurated a super specialty hospital in Belgaum.

    Heart Transplant Gives 63-Year-Old Man from Madanapalle a New Lease of Life

    KARNATAKA HEALTH MINISTER DINESH GUNDU RAO LAUNCHES DOCBRELLA.

    Mauritius to Host 2nd International Musculoskeletal Summit (IMS 2.0) 2025

    Cholera vaccination campaign launched in Darfur to protect over 1.8 million people

  • Technology
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    • Science

    NTT DATA Enhances Salesforce Capabilities with Strategic Acquisition of EXAH

    India’s Best Minds Must Power Defence Innovation for Vision 2047,” says CMD, BEL at CII AeroDef Tech Summit 2025

    150 students complete Sona Group’s Xccelerator 2.0 Programme powered by Unreal Engine, Dassault

    OPPO India launches F31 5G Series: The Best Smartphone for Durability with Smooth and powerful performance

    L&T Technology Services, SiMa.ai Collaborate for Product Innovation in Mobility, Healthcare, Industrial Automation & Robotics

    Apple Koregaon Park opens to customers this Thursday September 4 in Pune - PHOTO CREDIT-Apple

    Apple Koregaon Park opens to customers this Thursday, September 4, in Pune

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Sanofi to acquire Amunix immuno-oncology pipeline with next generation Conditionally Activated Biologics

FWM by FWM
December 21, 2021
in Business
0
  • Adds promising pipeline of T-cell engagers and cytokine therapies with lead candidate AMX-818 expected to enter the clinic in early 2022
  • Provides access to Amunix Pro-XTENTM, XPAT®, and XPACTM technology, complementary to Sanofi’s existing R&D platforms

PARIS – December 21, 2021 – Sanofi announced today that it has entered into an agreement to acquire Amunix Pharmaceuticals, Inc., an immuno-oncology company leveraging its proprietary, clinically validated XTEN® and innovative universal protease-releasable masking technology platform, Pro-XTENTM, to discover and develop transformative T-cell engagers (TCE) and cytokine therapies for patients with cancer. Amunix’s pipeline, which includes lead candidate, AMX-818, a masked HER2-directed TCE, offers a strong strategic fit with Sanofi’s focus on developing potentially transformative cancer therapies in immuno-oncology. Under the terms of the agreement, Sanofi will acquire Amunix for an upfront payment of approximately $1 billion and up to $225 million upon achievement of certain future development milestones. The acquisition supports Sanofi’s efforts to accelerate and expand its contributions to innovative medicines for oncology patients, with approximately 20 molecules currently in development.

“This acquisition demonstrates our ongoing commitment to investing in promising research and discovery platforms,” said John Reed, M.D., Ph.D., Global Head of Research & Development, Sanofi. “The Amunix technology platform utilizes a next generation smart biologics approach to precisely tailor–deliver medicines to become active only in tumor tissues while sparing normal tissues, thus bringing the promise of more effective and safer treatment options for cancer patients. We are excited to rapidly advance Amunix’s promising pipeline and to combine their innovative candidate medicines with complementary molecules in Sanofi’s immuno-oncology portfolio.”

Amunix’s proprietary XTEN® masks and cleavable linkers are a next-generation protein engineering approach that allows biologics to circulate in “stealth” mode, becoming active preferentially in disease specific micro-environments, with the aim to enable safer and more efficacious medicines. The technology can be applied to a wide range of existing and potentially new pipeline assets. The molecular design of Amunix’s molecules endows the inactive stealth molecules with long-lasting properties, converting after activation in disease tissues to short half-life agents so that the active molecule is rapidly cleared from the body. Specifically, in immuno-oncology, Amunix’s technology offers the potential to overcome challenges that have plagued the adoption of T-Cell Engager

bi-specific antibodies for solid tumors, including unwanted immune attack of normal healthy cells and systematic widespread immune system activation that leads to side effects such as Cytokine Release Syndrome.

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“We are very proud of what the extraordinary and diverse Amunix team has accomplished in the development of our Pro-XTEN technology and rapid expansion of our pipeline,” said Angie You, Ph.D., CEO, Amunix. 

“We now look forward to combining forces with Sanofi’s team to leverage its expertise and together serve as a center of excellence in bringing these potentially better and safer drug candidates to patients,” said Volker Schellenberger, Ph.D., Co-Founder, President and Chief Technology Officer, Amunix.

The closing of the transaction is subject to expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 and other customary closing conditions. Sanofi expects to complete the acquisition in Q1 of 2022.

Weil, Gotshal & Manges LLP is acting as Sanofi’s legal counsel. Centerview Partners LLC is acting as financial advisor to Amunix and Fenwick & West LLP is acting as its legal counsel.

XTEN, XPAT, XPAC and PRO-XTEN are trademarks in the name of Amunix.

Tags: Amunix PharmaceuticalsCenterview Partners LLCIncWeil Gotshal & Manges LLP
FWM

FWM

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