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    Global childhood vaccination coverage holds steady, yet over 14 million infants remain unvaccinated – WHO, UNICEF

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    HAL receives first set of wing assemblies for LCA Mk1A from L&T

    Emerson NI Days India 2025

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    KUSHAL’S FASHION JEWELLERY MARKS MILESTONE OF 100 STORES, AIMS TO REACH 150 BY THE END OF THIS FINANCIAL YEAR

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    “The relaunch is our way of expressing gratitude to our early patrons and reintroducing the space with renewed energy.”-Mr. Arup Chatterjee Regional Manger South spokesperson from Barbeque Nation Hospitality Ltd.

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    Glion awarded prestigious Swiss Federal Accreditation

    Global childhood vaccination coverage holds steady, yet over 14 million infants remain unvaccinated – WHO, UNICEF

    New WHO guidelines for clinical management of arboviral diseases: dengue, chikungunya, Zika and yellow fever

    Air Canada Celebrates Canada Day with Limited-time Fare Discounts for Customers Flying from India

    Shah Rukh Khan to Grace the Grand Opening of City of Dreams Sri Lanka

    Shah Rukh Khan to Grace the Grand Opening of City of Dreams Sri Lanka

    Left to Right- Ishfaaq Uvaim, Manager Telangana and Andhra Pradesh;  Mr. Dheera Hettiarachchi, Chairman, Sri Lanka Convention Bureau;  Mrs. Harsha Ruparathne, Actg. Deputy High Commissioner, Sri Lanka Deputy High Commission in Chennai, India;  Mrs. Malkanthi Welikala, Manager – Marketing, SLCB

    Sri Lanka Tourism boosts Indian MICE Engagement with Dynamic and Exclusive Networking Evening in TAJ Krishna, Hyderabad

  • National
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    SPREE scheme implemented for the welfare of workers

    KUSHAL’S FASHION JEWELLERY MARKS MILESTONE OF 100 STORES, AIMS TO REACH 150 BY THE END OF THIS FINANCIAL YEAR

    HAL receives first set of wing assemblies for LCA Mk1A from L&T

    NHRC, India takes suo motu cognizance of the reported gang rape of a woman in an empty compartment of a stationary train in Panipat city of Haryana

    “Virgin Boys” – A Bold Telugu Youth Drama Captures Hearts Across Theatres

    “Ishaara Samajh Le”: A Musical Call for Celebrations with Magic Moments & Kriti Sanon

  • Business

    Reliance Retail Acquires Kelvinator: Forging a New Era in India’s Consumer Durables Market

    ” Karnataka is not just India’s innovation and investment capital, we are steadily positioning ourselves as a global strategic R&D hub.”-Mr Priyank Kharge,Minister for IT & Biotechnology & Rural Development & Panchayati Raj, Gok.

    Commercial Taxes department’s clarification regarding Digital and Gateway Payments

  • Health

    Global childhood vaccination coverage holds steady, yet over 14 million infants remain unvaccinated – WHO, UNICEF

    “The relaunch is our way of expressing gratitude to our early patrons and reintroducing the space with renewed energy.”-Mr. Arup Chatterjee Regional Manger South spokesperson from Barbeque Nation Hospitality Ltd.

    Abbott Launches Digene Insta on the Go – Instant Relief from Acidity, Anytime, Anywhere

    Apollo AyurVAID Launches India’s First ‘Tested Safe’ Ayurveda Products

    Ichnos Glenmark Innovation (IGI) Announces Global Commercialization Strategy for ISB 2001 Following Licensing Deal with AbbVie

    New WHO guidelines for clinical management of arboviral diseases: dengue, chikungunya, Zika and yellow fever

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    • Science

    HAL receives first set of wing assemblies for LCA Mk1A from L&T

    Emerson NI Days India 2025

    Industry leaders unveil innovative solutions for print, branding, signage and digital displays.

    “This University Is Not Just an Institution—It’s a Mini City of Engineers”: Union Minister Scindia

    SatSure and Dhruva Space Unite to Launch India’s First Full-Stack Earth Observation-as-a-Service Ecosystem

    “SEZs can be a bridge between Indian and global aerospace and defence industries via Startup India.”-Piyush Goyal ,Union Minister for Commerce and Industry 

  • Auto

    Lucid, Nuro, and Uber Partner on Next-Generation Autonomous Robotaxi Program

    Volvo Cars reports Q2 2025 results, turnaround plan is fully on track

    Baneswar Banerjee, President & NSH, Mahindra, Deepak Sinha, NSH & Service Delivery, Mahindra EV and senior officials inaugurated PPS Mahindra showroom at Kanakapura Road

    PPS Motors inaugurates new Mahindra Showroom at Kanakapura Road, Bengaluru

    THE ALL-NEW LEAF. THE THIRD-GENERATION ELECTRIC VEHICLE (EV) LAUNCHED

  • Sports

    ‘The corner defender is the pillar of the team:’ Yogesh Dahiya on his record-breaking Bulls move

    Breaking Barriers, Smashing Limits: Adani Sportsline’s Lakshmi Jadala Qualifies for Special Olympics 2027

    TAG HEUER ANNOUNCES PARTNERSHIP WITH NEW YORK ROAD RUNNERS AS OFFICIAL TIMEKEEPER OF THE TCS NEW YORK CITY MARATHON

    Star-studded Auction Pool Awaits as Maharaja Trophy KSCA T20 Returns

  • Entertainment

    “Virgin Boys” – A Bold Telugu Youth Drama Captures Hearts Across Theatres

    Vogue Wedding Atelier presented by HSBC India at Taj Palace, New Delhi, from 8-10 August 2025

    A New Era in Luxury Weddings – Vogue Wedding Atelier Debuts in India

    GenS Life and Dowith Lit Present ‘Senior Spotlight’: Bengaluru’s Open Mic Celebration for the 55+

    PMJ Jewels Launches PMJ SuperStar Bracelet and ‘Celebrating Daughters’ Campaign

    ‘Waves’ an OTT platform that offers clean family-friendly content: Sunil Bhatiya, Deputy Director General, Doordarshan Kendra, Panaji

    Sri Sai Gold Palace’s 7th store inaugurated in Malleshwaram,Bengaluru.

  • Lifestyle
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    KUSHAL’S FASHION JEWELLERY MARKS MILESTONE OF 100 STORES, AIMS TO REACH 150 BY THE END OF THIS FINANCIAL YEAR

    Lab-Grown Trend? SWA Diamonds Flies High Globally with 100% Natural Gems

    Bangalore gets its very first “Paradise Kebab fest”

    Radisson Blu MBD Hotel Noida Marks Their 80th Milestone with the Launch of Ashok Karya, A Movement of Purpose

    Protect Your Hair Like Your Skin Season’s Essentials for Every Hair Type

    “The relaunch is our way of expressing gratitude to our early patrons and reintroducing the space with renewed energy.”-Mr. Arup Chatterjee Regional Manger South spokesperson from Barbeque Nation Hospitality Ltd.

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Sun Pharma Announces Late-Breaking Phase 2 Data Showing Potential of ILUMYA™ (tildrakizumab-asmn) to Improve Joint and Skin Symptoms of Psoriatic Arthritis

FWM by FWM
June 14, 2019
in Health
0

First Trial of ILUMYA™ in Patients with Psoriatic Arthritis Met Primary Efficacy Endpoint, with No Evident Safety Concerns

  • Over 71% of Patients Treated with ILUMYA™ Achieved ACR20 Response After 24 Weeks, with Significant Improvement as Early as 8 Weeks

Mumbai, India and Princeton, NJ, June 14, 2019 – Sun Pharmaceutical Industries Ltd. (Reuters: SUN.BO, Bloomberg: SUNP IN, NSE: SUNPHARMA, BSE: 524715, “Sun Pharma” and includes its subsidiaries and/or associate companies) today announced interim results from a Phase 2 study of interleukin-23 (IL-23) inhibitor ILUMYATM (tildrakizumab-asmn) in patients with active psoriatic arthritis that was presented in a late-breaking oral presentation at the Annual European Congress of Rheumatology (EULAR 2019) in Madrid, Spain (abstract #LB-0002).1 The interim analysis revealed that over 71 percent of patients treated with ILUMYA™ experienced a 20 percent improvement in joint and skin symptoms (ACR20), meeting the primary endpoint of the study. The interim results showed ILUMYA™ was well tolerated with a low rate of serious treatment-emergent adverse events.

ILUMYA™ is approved in the U.S. for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy and is being investigated for psoriatic arthritis. Psoriatic arthritis, which affects up to 42 percent of people with plaque psoriasis, is an inflammatory condition that impacts both the joints and skin. It is painful, causes fatigue, and can lead to swelling and stiffness of the joints that may reduce range of motion. If left untreated, this chronic condition can lead to permanent joint damage.2,3,4

“As a researcher and clinician, it’s encouraging to see these improvements in pain, joint swelling and skin plaques. Our interim findings showed that about half of the patients treated with 100 mg or 200 mg of tildrakizumab saw a 50 percent improvement in psoriatic arthritis symptoms and about a quarter saw a 70 percent improvement within 24 weeks,” said study investigator Philip J. Mease, MD, MACR, director of rheumatology research at the Swedish Medical Center/Providence St Joseph Health and clinical professor at the University of Washington School of Medicine, Seattle, WA. “These data insights are promising for patients who continue to struggle with the impact psoriatic arthritis has on their daily lives.”

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The Phase 2 study interim results showed that across all patients receiving ILUMYA™, 75.3 percent experienced a 20 percent improvement in symptoms of psoriatic arthritis (ACR20) at week 24 compared to 50.6 percent of patients on placebo. The findings were similar in patients receiving 100 mg or 200 mg of ILUMYA™ on a quarterly dosing schedule. For some patients on 100 mg ILUMYA™, results were seen as early as 8 weeks. Furthermore, an average of 47.1 percent of all patients receiving ILUMYA™ achieved an ACR50 response with some results seen as early as 12 weeks, compared to 24.1 percent of patients on placebo.

The interim results also showed ILUMYA™ was well tolerated with a low and comparable rate of adverse events to placebo. Serious treatment-emergent adverse events occurred in 2.2 percent of patients treated with ILUMYA™ and 2.5 percent in those on placebo, with no patients discontinuing treatment due to these events. The most common adverse events through week 24 included common cold (nasopharyngitis), upper respiratory tract infection, and headache. There were no reports of candidiasis, inflammatory bowel disease, major adverse cardiac events, malignancy, or deaths.

“We are committed to the continued clinical development of ILUMYA™ and are pleased with the interim results in our first study for psoriatic arthritis,” said Kyle Ferguson, Business Unit Head, Vice President Sales & Marketing, Sun Pharma. “To help us determine the potential of ILUMYA™ across psoriatic disease, we are now exploring a possible Phase 3 trial for psoriatic arthritis with regulatory authorities.”

Tags: Sun Pharmaceutical Industries Ltd.
FWM

FWM

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